SCHEMBL28030867

SCHEMBL28030867

c1ccc2c(C3CNCCO3)nccc2c1

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 0.45
HTR2A P28223 1/20 0.45
NPC1 O15118 1/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
DDB1 Q16531 1/20 0.42
CRBN Q96SW2 1/20 0.42
HTR2C P28335 1/20 0.41
DRD3 P35462 1/20 0.40
HRH1 P35367 1/20 0.39
KCNH2 Q12809 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11275044 0.78 DRD2 (0.45) DRD2HTR2ADRD3HRH1KCNH2
SCHEMBL28463116 0.78 SMN1; SMN2 (0.46) NPC1ALDH1A1MAPTRAB9ASMN1; SMN2
SCHEMBL28926587 0.77 SMN1; SMN2 (0.45) NPC1ALDH1A1MAPTRAB9ASMN1; SMN2
SCHEMBL20525268 0.77 MAPT (0.45) NPC1ALDH1A1MAPTRAB9ASMN1; SMN2
SCHEMBL28256052 0.77 NPC1 (0.45) NPC1ALDH1A1MAPTRAB9ASMN1; SMN2
SCHEMBL28257239 0.76 DRD2 (0.43) DRD2HTR2ADRD3
SCHEMBL2599486 0.76 DRD2 (0.49) DRD2HTR2ADRD3KCNH2
SCHEMBL28860435 0.75 DRD2 (0.41) DRD2HTR2ADRD3
Hydrochloric Acid SCHEMBL2599503 0.75 DRD2 (0.48) DRD2HTR2ADRD3KCNH2
SCHEMBL28666083 0.75 DRD2 (0.50) DRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104870422-B Amine derivative or its salt 富士胶片富山化学株式会社 2019-03-15 CN disclosed
CN-104870422-A Novel amine derivative or salt thereof TOYAMA CHEMICAL CO LTD 2015-08-26 CN disclosed