Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.54 |
| ▸ | TLR2 | O60603 | 3/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | PPARD | Q03181 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL28349868 | 1.00 | PRCP (0.54) | PRCPTLR2DPP7NAAAALDH1A1 | |
| Proline SCHEMBL27927743 | 1.00 | PRCP (0.54) | PRCPTLR2DPP7NAAAALDH1A1 | |
| Proline SCHEMBL27667835 | 1.00 | PRCP (0.54) | PRCPTLR2DPP7NAAAALDH1A1 | |
| Proline SCHEMBL28031789 | 0.92 | PRCP (0.47) | PRCPALDH1A1PPARGPPARDPPARA | |
| Dodecanoate SCHEMBL17223917 | 0.88 | PRCP (0.56) | PRCPTLR2ALDH1A1PPARGPPARD | |
| Dodecanoate SCHEMBL17223919 | 0.88 | PRCP (0.56) | PRCPTLR2ALDH1A1PPARGPPARD | |
| Decanoic Acid SCHEMBL13279505 | 0.88 | PRCP (0.56) | PRCPTLR2ALDH1A1PPARGPPARD | |
| Palmitamide SCHEMBL2983852 | 0.87 | PRCP (0.55) | PRCPTLR2DPP7NAAAALDH1A1 | |
| Palmitamide SCHEMBL2983849 | 0.87 | PRCP (0.55) | PRCPTLR2DPP7NAAAALDH1A1 | |
| Proline SCHEMBL28032319 | 0.85 | PRCP (0.56) | PRCPTLR2DPP7NAAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104955472-A | Fatty acid acylated amino acids for growth hormone delivery | NOVO NORDISK HEALTHCARE AG | 2015-09-30 | — | — | CN | disclosed |