Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 5/20 | 0.47 |
| ▸ | PPARD | Q03181 | 5/20 | 0.47 |
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | F7 | P08709 | 4/20 | 0.47 |
| ▸ | F3 | P13726 | 4/20 | 0.47 |
| ▸ | TERT | O14746 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | FABP4 | P15090 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL27667835 | 0.92 | PRCP (0.54) | PRCPPPARGPPARDPPARAPTPN1 | |
| Proline SCHEMBL27927743 | 0.92 | PRCP (0.54) | PRCPPPARGPPARDPPARAPTPN1 | |
| Proline SCHEMBL28349868 | 0.92 | PRCP (0.54) | PRCPPPARGPPARDPPARAPTPN1 | |
| Proline SCHEMBL28031772 | 0.92 | PRCP (0.54) | PRCPPPARGPPARDPPARAPTPN1 | |
| Linoleic Acid SCHEMBL1173765 | 0.86 | PPARG (0.63) | PPARGPPARDPPARAF7F3 | |
| Linoleic Acid SCHEMBL1173767 | 0.86 | PPARG (0.63) | PPARGPPARDPPARAF7F3 | |
| Dodecanoate SCHEMBL17223917 | 0.81 | PRCP (0.56) | PRCPPPARGPPARDPPARAPTPN1 | |
| Decanoic Acid SCHEMBL13279505 | 0.81 | PRCP (0.56) | PRCPPPARGPPARDPPARAPTPN1 | |
| Palmitamide SCHEMBL2983852 | 0.80 | PRCP (0.55) | PRCPCYP1A2CYP2C19FAAHKMT2A | |
| Linolenic Acid SCHEMBL1173186 | 0.79 | ALDH1A1 (0.63) | PPARGPPARDPPARAF7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104955472-A | Fatty acid acylated amino acids for growth hormone delivery | NOVO NORDISK HEALTHCARE AG | 2015-09-30 | — | — | CN | disclosed |