SCHEMBL28033037

SCHEMBL28033037

NCc1ccc(C2(C(=O)N3CCC(c4ccncc4)C3)CC2)cc1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 19/20 0.73
SPR P35270 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL348520 0.86 HSD11B1 (0.80) HSD11B1SPR
SCHEMBL350357 0.85 HSD11B1 (0.78) HSD11B1SPR
SCHEMBL348945 0.85 HSD11B1 (1.00) HSD11B1SPR
SCHEMBL348150 0.85 HSD11B1 (1.00) HSD11B1SPR
SCHEMBL350158 0.85 HSD11B1 (1.00) HSD11B1SPR
SCHEMBL350995 0.83 HSD11B1 (0.75) HSD11B1SPR
SCHEMBL349656 0.83 HSD11B1 (0.75) HSD11B1
SCHEMBL351071 0.80 HSD11B1 (0.64) HSD11B1
SCHEMBL348226 0.80 HSD11B1 (0.71) HSD11B1SPR
SCHEMBL350011 0.79 HSD11B1 (0.66) HSD11B1SPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101001842-B Amido compounds and the application as medicine thereof INCYTE CORP. (US) 2015-10-07 CN disclosed