Sugi Predict

Sugi Predict / Compounds / SCHEMBL280333

SCHEMBL280333

SCHEMBL280333

COC(=O)CCCC(=O)C(=O)OC

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 4/20 0.71
▸ LMNA P02545 3/20 0.45
▸ ALDH1A1 P00352 2/20 0.45
▸ KMT2A Q03164 3/20 0.44
▸ MEN1 O00255 2/20 0.44
▸ GLA P06280 1/20 0.43
▸ TET2 Q6N021 1/20 0.41
▸ HDAC3 O15379 3/20 0.40
▸ HDAC4 P56524 3/20 0.40
▸ HDAC1 Q13547 3/20 0.40
▸ HDAC7 Q8WUI4 3/20 0.40
▸ HDAC2 Q92769 3/20 0.40
▸ HDAC10 Q969S8 3/20 0.40
▸ HDAC11 Q96DB2 3/20 0.40
▸ HDAC8 Q9BY41 3/20 0.40
▸ HDAC6 Q9UBN7 3/20 0.40
▸ HDAC9 Q9UKV0 3/20 0.40
▸ HDAC5 Q9UQL6 3/20 0.40
▸ CA12 O43570 1/20 0.40
▸ CA14 Q9ULX7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7421083 0.95 TSHR (0.64) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL22310268 0.93 TSHR (0.61) TSHRLMNAALDH1A1KMT2ATET2
SCHEMBL9543 0.85 TSHR (0.68) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL28238018 0.84 TSHR (1.00) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL50039 0.84 TSHR (1.00) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL23930671 0.83 TSHR (0.60) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL20834320 0.83 TSHR (0.48) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL2562654 0.82 TSHR (0.74) TSHRLMNAALDH1A1KMT2AMEN1
SCHEMBL11382492 0.82 TSHR (0.58) TSHRLMNAALDH1A1KMT2AMEN1
Dimethyl Succinate SCHEMBL7262656 0.82 TSHR (0.94) TSHRLMNAALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12331038-B2 Hexone glucokinase inhibitor and use thereof SHANDONG XUANZHU PHARMA CO., LTD. (CN) 2025-06-17 — — US disclosed
CN-116023365-B Ketohexokinase inhibitors and uses thereof 轩竹生物科技股份有限公司 2025-02-14 — — CN disclosed
US-20240067633-A1 KETOHEXOKINASE INHIBITOR AND USE THEREOF XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) 2024-02-29 — — US disclosed
US-20240067633-A1 KETOHEXOKINASE INHIBITOR AND USE THEREOF XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) 2024-02-29 — — US disclosed
EP-4269404-A1 KETOHEXOKINASE INHIBITOR AND USE THEREOF Sichuan Haisco Pharmaceutical Co., Ltd. (CN) 2023-11-01 — — EP disclosed
US-20230271947-A1 SALT AND CRYSTAL FORM OF KETOHEXOKINASE INHIBITOR AND USE THEREOF Xuanzhu Biopharmaceutical Co., Ltd. (CN) 2023-08-31 — — US disclosed
US-20230271947-A1 SALT AND CRYSTAL FORM OF KETOHEXOKINASE INHIBITOR AND USE THEREOF Xuanzhu Biopharmaceutical Co., Ltd. (CN) 2023-08-31 — — US disclosed
CN-116635377-A Ketohexokinase inhibitors and uses thereof 四川海思科制药有限公司 2023-08-22 — — CN disclosed
CN-113999212-B Salts, crystalline forms and uses of ketohexokinase inhibitors 山东轩竹医药科技有限公司 2023-07-28 — — CN disclosed
EP-4190776-A1 SALT AND CRYSTAL FORM OF KETOHEXOKINASE INHIBITOR AND USE THEREOF Shandong Xuanzhu Pharma Co., Ltd. (CN) 2023-06-07 — — EP disclosed
US-20120258504-A1 BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL ALKANES FROM CARBOHYDRATE FEEDSTOCKS CELEXION, LLC (US) 2012-10-11 — — US disclosed
US-20120164702-A1 BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL ALKANES FROM CARBOHYDRATE FEEDSTOCKS CELEXION, LLC (US) 2012-06-28 — — US disclosed
US-8192976-B2 Biological synthesis of difunctional alkanes from carbohydrate feedstocks CELEXION, LLC (US) 2012-06-05 — — US disclosed
US-8133704-B2 Biological synthesis of difunctional alkanes from carbohydrate feedstocks CELEXION, LLC (US) 2012-03-13 — — US disclosed
US-20110171696-A1 Biological Synthesis of Difunctional Alkanes from Carbohydrate Feedstocks CELEXION, LLC (US) 2011-07-14 — — US disclosed
US-20100151536-A1 Biological Synthesis of Difunctional Alkanes from Carbohydrate Feedstocks CELEXION, LLC 2010-06-17 — — US disclosed
US-20100056432-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIBACTERIAL ACTIVITY POLYPHOR LTD. (CH) 2010-03-04 — — US disclosed
US-7582604-B2 Template-fixed peptidomimetics with antibacterial activity POLYPHOR LTD. (CH) 2009-09-01 — — US disclosed
US-7417024-B2 Template-fixed peptidomimetics as inhibitors of serine proteases POLYPHOR LTD. (CH) 2008-08-26 — — US disclosed
US-7253146-B2 Template-fixed peptidomimetics with antimicrobial activity POLYPHOR LTD (CH) 2007-08-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230271947-A1 SALT AND CRYSTAL FORM OF KETOHEXOKINASE INHIBITOR AND USE THEREOF KHK, HK1, HKDC1 TSHR 3782/4885LMNA 4307/4885ALDH1A1 1879/4885
US-12331038-B2 Hexone glucokinase inhibitor and use thereof GCK, KHK, HK1 TSHR 4107/4885LMNA 3928/4885ALDH1A1 1698/4885
US-20100056432-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIBACTERIAL ACTIVITY POLL, QPCTL, PEPD TSHR 3262/4885LMNA 1043/4885ALDH1A1 1705/4885
US-20240067633-A1 KETOHEXOKINASE INHIBITOR AND USE THEREOF KHK, GCK, HK1 TSHR 3408/4885LMNA 3682/4885ALDH1A1 710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.