HKDC1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
2-Chloro-3-Morpholino-1,4-Naphthoquinone (SCHEMBL197256)	0.58	4/20
SCHEMBL299444	1.00	3/20
Sennoside A (SCHEMBL440792)	1.00	3/20
Sennoside B (SCHEMBL441194)	1.00	3/20
SCHEMBL247037	0.79	3/20
SCHEMBL290276	0.69	3/20
SCHEMBL290290	0.69	3/20
SCHEMBL459004	0.55	3/20
SCHEMBL299016	0.54	3/20
Aloin (SCHEMBL181616)	0.52	3/20
SCHEMBL244406	0.51	3/20
SCHEMBL29385	0.43	3/20
SCHEMBL146609	0.40	3/20
SCHEMBL45662	0.38	3/20
SCHEMBL31762	0.34	3/20
SCHEMBL170388	1.00	2/20
SCHEMBL249168	0.77	2/20
SCHEMBL409989	0.76	2/20
SCHEMBL412644	0.74	2/20
SCHEMBL298938	0.72	2/20

Clinical trials — most relevant to HKDC1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus.	PHASE3	COMPLETED
Ketohexokinase Inhibition in NAFLD	PHASE2	COMPLETED
Bempedoic Acid Therapy for Polycystic Kidney Disease	PHASE2	NOT_YET_RECRUITING
Epirubicin, Docetaxel, and Capecitabine in Treating Women With Stage IIIA or Stage IIIB Breast Cancer	PHASE2	COMPLETED
First-line Irinotecan, Lederfolin and 5FU (FOLFIRI) and Bevacizumab in Patients With Advanced Colorectal Cancer	PHASE2	COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
A Study of AK138D1 in Advanced Malignant Tumors	PHASE1	RECRUITING
Combination of Chemoradiation Therapy and Epitope Peptide Vaccine Therapy in Treating Patients With Esophageal Cancer	PHASE1	UNKNOWN
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
3'-Deoxy-3'-[18F] Fluorothymidine and Fludeoxyglucose F 18 PET Scans in Evaluating Response to Cetuximab, Cisplatin, and Radiation Therapy in Patients With Advanced Cancer of the Oropharynx, Larynx, or Hypopharynx	EARLY_PHASE1	COMPLETED
PET/CT to Image Hypoxia in Head and Neck Tumours	EARLY_PHASE1	COMPLETED
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Transformative Research in Diabetic Nephropathy	nan	RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
13C Pyruvate DNP MR Spectroscopy for Lymphoma Treatment Response Assessment	nan	UNKNOWN
Genetic-specific Effects of Fructose on Liver Lipogenesis	nan	COMPLETED
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
REFUEL PCOS Study 1	nan	UNKNOWN
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People	nan	COMPLETED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
The Role of TBC1D4 in Exercise- and Insulin-induced Glucose Metabolism in Human Skeletal Muscle	nan	COMPLETED
Evaluation of HPGD and SCLO2A1 Expression in Clear Cell Renal Cell Carcinoma Patients	nan	COMPLETED
Dual PETOvac - Dual Time PET/CT in the Preoperative Assessment of Ovarian Cancer	nan	UNKNOWN
Genetic Association of Diabetic Retinopathy-1	nan	UNKNOWN
Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.	nan	RECRUITING
Outcome of Use of a Novel Modulator of Oxidative Phosphorylation on Kidney Function in Patients With Progressive Chronic Kidney Disease	nan	COMPLETED
Multi-Tracer PET Quantitation of Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus	nan	COMPLETED
Diagnostic Significance of Single Center, Open and Prospective Evaluation of 18F-FDG PET/CT Dynamic Imaging and Genomic Sequencing in Detecting Metastatic Lesions and Differentiating Multiple Primary Lung Cancer From Intrapulmonary Metastases of Non-small Cell Lung Cancer	nan	UNKNOWN
Mechanisms of Exercise Resistance in Metabolic Disease	nan	COMPLETED
Anti-inflammatory Dietary Intervention in Overweight and Obese Adolescents	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HKDC1 binder may also engage these)

Protein	Name	Similarity
Q91W97	—	1.000	Q91W97 →
P27881	—	1.000	P27881 →
A2PYL8	—	1.000	A2PYL8 →
P05708	—	1.000	P05708 →
P17710	—	1.000	P17710 →
P27595	—	1.000	P27595 →
HK2	Hexokinase-2	1.000	landscape →
HK1	Hexokinase-1	1.000	landscape →
Q5RC71	—	1.000	Q5RC71 →
A2PYL7	—	0.999	A2PYL7 →
O08528	—	0.998	O08528 →
A2PYL6	—	0.998	A2PYL6 →
Q1W674	—	0.998	Q1W674 →
Q3TRM8	—	0.995	Q3TRM8 →
Q9SQ76	—	0.993	Q9SQ76 →
Q42525	—	0.992	Q42525 →
GCK	Hexokinase-4	0.992	landscape →
Q9SEK2	—	0.992	Q9SEK2 →
Q1WM16	—	0.992	Q1WM16 →
P52792	—	0.992	P52792 →
Q2KNB7	—	0.991	Q2KNB7 →
P17712	—	0.990	P17712 →
P27926	—	0.987	P27926 →
Q9NFT7	—	0.987	Q9NFT7 →
Q2KNB9	—	0.986	Q2KNB9 →
Q6Z398	—	0.986	Q6Z398 →
Q2KNB5	—	0.986	Q2KNB5 →
P93834	—	0.985	P93834 →
P80581	—	0.984	P80581 →
P52790	—	0.984	P52790 →