Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Danthron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.95 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.95 |
| ▸ | MAOA | P21397 | 3/20 | 0.95 |
| ▸ | TSHR | P16473 | 3/20 | 0.95 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.95 |
| ▸ | HPGD | P15428 | 3/20 | 0.95 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.95 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.95 |
| ▸ | LMNA | P02545 | 2/20 | 0.95 |
| ▸ | MAOB | P27338 | 2/20 | 0.95 |
| ▸ | HTT | P42858 | 1/20 | 0.95 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | ELANE | P08246 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | RECQL | P46063 | 5/20 | 0.67 |
| ▸ | CTSG | P08311 | 4/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Danthron SCHEMBL28033049 | 0.98 | MAPT (0.91) | MAPTALDH1A1TDP1MAOATSHR | |
| Danthron SCHEMBL83688 | 0.98 | MAPT (1.00) | MAPTALDH1A1TDP1MAOATSHR | |
| Danthron SCHEMBL29356886 | 0.98 | MAPT (1.00) | MAPTALDH1A1TDP1MAOATSHR | |
| Danthron SCHEMBL30544826 | 0.98 | MAPT (1.00) | MAPTALDH1A1TDP1MAOATSHR | |
| Danthron SCHEMBL27944089 | 0.95 | MAPT (0.95) | MAPTALDH1A1TDP1MAOATSHR | |
| Danthron SCHEMBL20565674 | 0.95 | MAPT (0.95) | MAPTALDH1A1TDP1MAOATSHR | |
| Danthron SCHEMBL30721499 | 0.95 | MAPT (0.95) | MAPTALDH1A1TDP1MAOATSHR | |
| Danthron SCHEMBL27939625 | 0.95 | MAPT (0.95) | MAPTALDH1A1TDP1MAOATSHR | |
| Danthron SCHEMBL28154156 | 0.95 | MAPT (0.95) | MAPTALDH1A1TDP1MAOATSHR | |
| Danthron SCHEMBL28137084 | 0.93 | MAPT (0.91) | MAPTALDH1A1TDP1MAOATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105061181-A | 1,8-dyhydroxy-anthraquinone magnesium compound and preparation method thereof | XIAN MODERN CHEMISTRY RES INST | 2015-11-18 | — | — | CN | claimed |
| CN-117339522-A | Particle size controllable synthesis method and device for anthraquinone magnesium compound | 中北大学 | 2024-01-05 | — | — | CN | disclosed |
| CN-105061181-A | 1,8-dyhydroxy-anthraquinone magnesium compound and preparation method thereof | XIAN MODERN CHEMISTRY RES INST | 2015-11-18 | — | — | CN | disclosed |
| CN-105061181-A | 1,8-dyhydroxy-anthraquinone magnesium compound and preparation method thereof | XIAN MODERN CHEMISTRY RES INST | 2015-11-18 | — | — | CN | disclosed |
| CN-105061181-A | 1,8-dyhydroxy-anthraquinone magnesium compound and preparation method thereof | XIAN MODERN CHEMISTRY RES INST | 2015-11-18 | — | — | CN | disclosed |