SCHEMBL28034686

SCHEMBL28034686

Oc1ccc(-c2cccnc2)c(O)c1-c1cccnc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.52
CYP2A6 P11509 5/20 0.52
CYP1A2 P05177 2/20 0.52
ALDH1A1 P00352 2/20 0.52
ACLY P53396 2/20 0.50
CYP2D6 P10635 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2B6 P20813 2/20 0.50
CYP2C19 P33261 2/20 0.50
HSD17B1 P14061 1/20 0.50
HSD17B2 P37059 1/20 0.50
CYP11B1 P15538 5/20 0.49
CYP11B2 P19099 4/20 0.49
CYP17A1 P05093 3/20 0.49
ERN1 O75460 1/20 0.46
MAPT P10636 2/20 0.45
KDM4E B2RXH2 2/20 0.45
LMNA P02545 1/20 0.45
TP53 P04637 1/20 0.45
HPGD P15428 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5462328 0.95 ACLY (0.47) CYP3A4CYP2A6CYP1A2ALDH1A1ACLY
SCHEMBL5462846 0.84 ACLY (0.51) CYP3A4CYP2A6CYP1A2ALDH1A1ACLY
SCHEMBL5462852 0.82 KDM4E (0.49) CYP3A4CYP2A6CYP1A2ALDH1A1ACLY
SCHEMBL27802325 0.81 CYP2A6 (0.64) CYP3A4CYP2A6CYP1A2ALDH1A1CYP2D6
SCHEMBL18528875 0.81 CYP2A6 (0.52) CYP3A4CYP2A6CYP1A2ALDH1A1ACLY
SCHEMBL1155472 0.79 CYP2A6 (0.61) CYP3A4CYP2A6CYP1A2ALDH1A1CYP2D6
SCHEMBL12381483 0.78 CYP11B1 (0.61) CYP3A4CYP2A6CYP1A2ALDH1A1CYP2D6
SCHEMBL1491549 0.77 CYP2A6 (0.64) CYP3A4CYP2A6CYP1A2ALDH1A1ACLY
SCHEMBL11965538 0.76 CYP2A6 (0.78) CYP3A4CYP2A6CYP1A2ALDH1A1CYP2D6
SCHEMBL28674858 0.75 CYP2A6 (0.61) CYP3A4CYP2A6CYP1A2ALDH1A1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104974341-A Cross-linked polyarylether polymer and preparation method thereof UNIV JILIN 2015-10-14 CN claimed
CN-104974341-A Cross-linked polyarylether polymer and preparation method thereof UNIV JILIN 2015-10-14 CN disclosed