M-Xylene

M-Xylene

SCHEMBL28034890

Cc1cccc(C)c1.F[B-](F)(F)F.N#[NH+]

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 5/20 0.63
ALDH1A1 P00352 3/20 0.44
MAPK1 P28482 1/20 0.44
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
MAPT P10636 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
HTT P42858 1/20 0.43
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
HPGD P15428 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
TSHR P16473 2/20 0.41
TP53 P04637 2/20 0.40
POLB P06746 1/20 0.40
HSD17B10 Q99714 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
HSP90AA1 P07900 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
M-Xylene SCHEMBL19915253 0.89 ACHE (0.71) ACHEALDH1A1MAPK1CYP1A2CYP3A4
M-Xylene SCHEMBL909803 0.86 ACHE (0.67) ACHEALDH1A1MAPK1CYP1A2CYP3A4
Toluene SCHEMBL4857374 0.81 ACHE (0.61) ACHEALDH1A1MAPTNPC1RAB9A
Nitrogen SCHEMBL20184124 0.81 ACHE (0.73) ACHEALDH1A1CYP3A4NPC1RAB9A
M-Xylene SCHEMBL891494 0.80 ACHE (1.00) ACHEALDH1A1MAPK1CYP1A2CYP3A4
M-Xylene SCHEMBL6397624 0.80
M-Xylene SCHEMBL28189 0.80
M-Xylene SCHEMBL27786701 0.77 ACHE (0.80) ACHEALDH1A1MAPK1CYP1A2CYP3A4
SCHEMBL19260368 0.77 ACHE (0.85) ACHEALDH1A1MAPK1CYP1A2CYP3A4
M-Xylene SCHEMBL18045662 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106045836-B A kind of method of copper catalysis synthesis aromatic hydrocarbons or heterocycle trifluoromethyl ketone 福州大学 2018-04-13 CN disclosed
CN-106045836-A Method for synthesizing aromatic hydrocarbon or heterocyclic trifluoromethylketone under catalytic action of copper 福州大学 2016-10-26 CN disclosed
CN-105120865-A Muscarinic agonists ACADIA PHARM INC 2015-12-02 CN disclosed