Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Chalcone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.96 |
| ▸ | CYP1B1 | Q16678 | 10/20 | 0.96 |
| ▸ | MAPT | P10636 | 6/20 | 0.96 |
| ▸ | MAOB | P27338 | 6/20 | 0.96 |
| ▸ | LMNA | P02545 | 2/20 | 0.96 |
| ▸ | BCHE | P06276 | 2/20 | 0.96 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.96 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.96 |
| ▸ | RECQL | P46063 | 1/20 | 0.96 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.96 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.75 |
| ▸ | HSPD1 | P10809 | 3/20 | 0.75 |
| ▸ | HSPE1 | P61604 | 3/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.75 |
| ▸ | RAB9A | P51151 | 2/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.75 |
| ▸ | RELA | Q04206 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chalcone SCHEMBL8688527 | 1.00 | CYP1B1 (0.96) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL8688533 | 1.00 | CYP1B1 (0.96) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL28306720 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL27581 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL29396001 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL29922932 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL2404758 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL454583 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL27580 | 0.98 | CYP1B1 (1.00) | CYP1B1MAPTMAOBLMNABCHE | |
| Chalcone SCHEMBL2427445 | 0.96 | CYP1B1 (0.96) | CYP1B1MAPTMAOBLMNABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104987284-A | Organic nonlinear optical compound chalcone dibromide synthetic method | TIANCHANG TIANJIA CHEMICAL TECHNOLOGY CO LTD | 2015-10-21 | — | — | CN | disclosed |
| CN-104987284-A | Organic nonlinear optical compound chalcone dibromide synthetic method | TIANCHANG TIANJIA CHEMICAL TECHNOLOGY CO LTD | 2015-10-21 | — | — | CN | disclosed |