Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.55 |
| ▸ | CFTR | P13569 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.55 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | QPCT | Q16769 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910376 | 0.78 | GPR35 (0.60) | CYP1A2CYP1A1CYP1B1CFTRPOLB | |
| SCHEMBL2148872 | 0.78 | CYP1A2 (0.55) | CYP1A2CYP1A1CYP1B1CFTRPOLB | |
| SCHEMBL910079 | 0.78 | CYP1A2 (0.64) | CYP1A2CYP1A1CYP1B1CFTRPOLB | |
| SCHEMBL3698440 | 0.77 | CYSLTR1 (0.67) | CYP1A2CYP1A1CYP1B1CFTRPOLB | |
| SCHEMBL28822757 | 0.76 | CYP3A4 (0.48) | CYP1A2CYP1A1CYP1B1CYP3A4CYP2C19 | |
| SCHEMBL27702773 | 0.75 | MAPT (0.44) | CYP1A1CYP1B1CYP3A4CYP2C19MAPT | |
| SCHEMBL909886 | 0.75 | CYP1A2 (0.52) | CYP1A2CYP1A1CYP1B1CFTRPOLB | |
| SCHEMBL25260798 | 0.75 | CYP1A2 (0.64) | CYP1A2CYP1A1CYP1B1CFTRPOLB | |
| SCHEMBL30461668 | 0.75 | CYP1A2 (0.64) | CYP1A2CYP1A1CYP1B1CFTRPOLB | |
| SCHEMBL909747 | 0.75 | CYP1A2 (0.64) | CYP1A2CYP1A1CYP1B1CFTRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105198872-A | Chromenone analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2015-12-30 | — | — | CN | disclosed |
| CN-102227417-B | Chromenone analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS, INC. (US) | 2015-09-16 | — | — | CN | disclosed |