Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCKDK | O14874 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2471802 | 0.88 | EGLN3 (0.49) | EGLN2EGLN1EGLN3HIF1A | |
| SCHEMBL28796651 | 0.78 | BCKDK (0.38) | BCKDKMCL1RXFP1NPC1RAB9A | |
| SCHEMBL2470254 | 0.78 | EGLN1 (0.47) | EGLN2EGLN1EGLN3HIF1A | |
| SCHEMBL2468473 | 0.76 | KDM4C (0.44) | BCKDKMCL1RXFP1NPC1RAB9A | |
| SCHEMBL2468471 | 0.76 | KDM4C (0.44) | BCKDKMCL1RXFP1NPC1RAB9A | |
| SCHEMBL2472663 | 0.76 | HIF1A (0.46) | EGLN2EGLN1EGLN3HIF1A | |
| SCHEMBL2469098 | 0.75 | BCKDK (0.42) | BCKDKMCL1RXFP1NPC1RAB9A | |
| SCHEMBL2469231 | 0.74 | EGLN1 (0.47) | NPC1RAB9AEGLN1HIF1AMAPT | |
| SCHEMBL2470665 | 0.73 | HIF1A (0.51) | EGLN2EGLN1EGLN3HIF1A | |
| SCHEMBL2469283 | 0.73 | EGLN1 (0.58) | EGLN1EGLN3HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105037323-A | Thiochromene derivatives as HIF hydroxylase inhibitors | FIBROGEN INC | 2015-11-11 | — | — | CN | disclosed |