Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | FABP7 | O15540 | 1/20 | 0.52 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.52 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828627 | 0.82 | LMNA (0.58) | MEN1KMT2AFABP7FABP5HAO1 | |
| SCHEMBL27811220 | 0.82 | MEN1 (0.66) | MEN1KMT2APRSS1ACRMGLL | |
| SCHEMBL27669471 | 0.81 | FABP7 (0.49) | MEN1KMT2AFABP7FABP5HAO1 | |
| SCHEMBL14501378 | 0.81 | FABP7 (0.51) | MEN1KMT2AFABP7FABP5HAO1 | |
| SCHEMBL28692695 | 0.79 | MEN1 (0.61) | MEN1KMT2AHAO1CA12CA1 | |
| SCHEMBL13022988 | 0.79 | FABP7 (0.50) | MEN1KMT2AFABP7FABP5HAO1 | |
| SCHEMBL13022987 | 0.79 | FABP7 (0.50) | MEN1KMT2AFABP7FABP5HAO1 | |
| SCHEMBL13023059 | 0.79 | FABP7 (0.50) | MEN1KMT2AFABP7FABP5HAO1 | |
| SCHEMBL21612810 | 0.79 | HAO1 (0.42) | MEN1KMT2AFABP7FABP5HAO1 | |
| SCHEMBL14501374 | 0.78 | FABP7 (0.56) | MEN1KMT2AFABP7FABP5HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105142634-B | Oxindole carboxylic acid-based inhibitors of oncogenic protein tyrosine phosphatase-2(SHP2) comprising Src homology-2domain | 美国印第安纳大学研究和技术公司 | 2020-06-12 | — | — | CN | disclosed |
| CN-110423212-A | The inhibitor based on oxyindole carboxylic acid of SHP2 | UNIV INDIANA RES & TECH CORP | 2019-11-08 | — | — | CN | disclosed |
| CN-109476699-A | Glucocorticoid receptor agonist and its immune conjugate | 艾伯维公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-106458920-B | Alkynyl indazole derivative and application thereof | 千寿制药株式会社 | 2019-02-15 | — | — | CN | disclosed |
| CN-106458920-A | Alkynyl indazole derivative and use thereof | 千寿制药株式会社 | 2017-02-22 | — | — | CN | disclosed |
| CN-105142634-A | Oxindole carboxylic acid-based inhibitors of oncogenic protein tyrosine phosphatase-2 (SHP2) comprising Src homology-2 domain | UNIV INDIANA RES & TECH CORP | 2015-12-09 | — | — | CN | disclosed |