Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 3/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4603634 | 0.97 | MAPT (0.37) | MAPTMAPK1LMNAALDH1A1PDE4A | |
| Ammonia Solution, Strong SCHEMBL3964315 | 0.95 | MAPT (0.36) | MAPTMAPK1LMNAALDH1A1PDE4A | |
| SCHEMBL10795559 | 0.87 | MAPT (0.51) | MAPTMAPK1LMNAALDH1A1FAAH | |
| SCHEMBL769533 | 0.85 | MAPT (0.54) | MAPTMAPK1LMNAALDH1A1FAAH | |
| SCHEMBL6357113 | 0.85 | MAPT (0.54) | MAPTMAPK1LMNAALDH1A1FAAH | |
| SCHEMBL19458643 | 0.85 | MAPT (0.54) | MAPTMAPK1LMNAALDH1A1FAAH | |
| SCHEMBL15262436 | 0.85 | MAPT (0.54) | MAPTMAPK1LMNAALDH1A1FAAH | |
| SCHEMBL11801281 | 0.85 | MAPT (0.54) | MAPTMAPK1LMNAALDH1A1FAAH | |
| SCHEMBL373408 | 0.85 | MAPT (0.54) | MAPTMAPK1LMNAALDH1A1FAAH | |
| SCHEMBL2800456 | 0.85 | MAPT (0.54) | MAPTMAPK1LMNAALDH1A1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256187-A1 | Hepatocyte lineage cells derived from pluripotent stem cells | GERON CORPORATION (US) | 2010-12-01 | — | — | EP | disclosed |
| US-7282366-B2 | Hepatocytes for therapy and drug screening made from embryonic stem cells | GERON CORPORATION (US) | 2007-10-16 | — | — | US | disclosed |
| US-7256042-B2 | Process for making hepatocytes from pluripotent stem cells | GERON CORPORATION (US) | 2007-08-14 | — | — | US | disclosed |
| EP-1280887-A2 | HEPATOCYTE LINEAGE CELLS DERIVED FROM PLURIPOTENT STEM CELLS | Geron Corporation (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6506574-B1 | Drug screening, liver replenishment; culturing with cellular differentiation agent | GERON CORPORATION | 2003-01-14 | — | — | US | disclosed |
| US-20030003573-A1 | Hepatocytes for therapy and drug screening made from embryonic stem cells | ASTERIAS BIOTHERAPEUTICS, INC. | 2003-01-02 | — | — | US | disclosed |
| US-20020160511-A1 | Process for making hepatocytes from pluripotent stem cells | ASTERIAS BIOTHERAPEUTICS, INC. | 2002-10-31 | — | — | US | disclosed |
| US-6458589-B1 | CULTURED IN PRESENCE OF DIFFERENTIATION AGENT; DRUG SCREENING; REGENERATING LIVER FUNCTION | GERON CORPORATION | 2002-10-01 | — | — | US | disclosed |
| WO-2001081549-A2 | HEPATOCYTE LINEAGE CELLS DERIVED FROM PLURIPOTENT STEM CELLS | GERON CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |