Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381064 | 0.85 | ALDH1A1 (0.59) | MAPTALDH1A1LMNAMAPK1PTPN2 | |
| SCHEMBL32660771 | 0.82 | MAPT (0.67) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28266725 | 0.82 | GAA (0.49) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28037365 | 0.81 | MAPT (0.58) | MAPTMEN1KMT2AALDH1A1NAMPT | |
| SCHEMBL31267814 | 0.81 | MAPT (0.58) | MAPTMEN1KMT2AALDH1A1NAMPT | |
| SCHEMBL28037000 | 0.81 | GAA (0.64) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL29435691 | 0.81 | MAPT (0.68) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1392727 | 0.81 | MAPT (0.68) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28037394 | 0.80 | KDM4E (0.49) | MAPTALDH1A1KDM4EMAPK1PKM | |
| SCHEMBL26641270 | 0.80 | MAPT (0.70) | MAPTMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153119-A | Pyridylpyrimidyl amine compounds or pyridylpyridyl amine compounds and application thereof | GUANGZHOU KEQIN NEW MEDICINE DESIGN CO LTD | 2015-12-16 | — | — | CN | disclosed |