Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27747567 | 0.94 | AXL (0.41) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| SCHEMBL32388 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL21803551 | 0.92 | AXL (0.39) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| SCHEMBL30711136 | 0.92 | AXL (0.39) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Hydrazine SCHEMBL5897595 | 0.90 | AXL (0.38) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Urea SCHEMBL28122176 | 0.87 | AXL (0.34) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Acetic Acid SCHEMBL474261 | 0.85 | ADORA2A (0.35) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Pyrimidine SCHEMBL27714628 | 0.85 | EGFR (0.38) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| SCHEMBL29588937 | 0.84 | PIP4K2C (0.40) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Piperazine SCHEMBL21803298 | 0.83 | HTR2C (0.43) | AXLMKNK1MKNK2EGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003219-A | Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator | 弗·哈夫曼-拉罗切有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-105367577-B | Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator | 弗·哈夫曼-拉罗切有限公司 | 2019-04-23 | — | — | CN | disclosed |
| CN-105367577-A | Pyrazolo[1,5A]Pyrimidine Derivatives As Irak4 Modulators | HOFFMANN LA ROCHE | 2016-03-02 | — | — | CN | disclosed |
| CN-102985426-B | Pyrazolo [1,5A ] pyrimidine and thieno [3,2B ] pyrimidine derivatives as IRAK4 modulators | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-07 | — | — | CN | disclosed |