Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27747567 | 0.96 | AXL (0.41) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| SCHEMBL32388 | 0.96 | — | — | |
| SCHEMBL30711136 | 0.94 | AXL (0.39) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Hydrochloric Acid SCHEMBL21803551 | 0.94 | AXL (0.39) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Formaldehyde SCHEMBL28037402 | 0.90 | AXL (0.37) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Urea SCHEMBL28122176 | 0.89 | AXL (0.34) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Pyrimidine SCHEMBL27714628 | 0.86 | EGFR (0.38) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Piperazine SCHEMBL21803298 | 0.85 | HTR2C (0.43) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Pyridine SCHEMBL27578790 | 0.85 | EGFR (0.37) | AXLMKNK1MKNK2EGFRALDH1A1 | |
| Acetic Acid SCHEMBL474261 | 0.83 | ADORA2A (0.35) | AXLMKNK1MKNK2EGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39267-E1 | Thienopyrimidine-based inhibitors of the SRC family | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-09-05 | — | — | US | disclosed |
| US-6503914-B1 | Thienopyrimidine-based inhibitors of the Src family | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-01-07 | — | — | US | disclosed |