Trifluoromethylbenzene

Trifluoromethylbenzene

SCHEMBL28037899

FC(F)(F)c1ccccc1.Nc1ncnc(N)n1

nearest known ligand 0.56

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Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.56
ALDH1A1 P00352 1/20 0.56
KDM4E B2RXH2 2/20 0.54
ADORA2A P29274 2/20 0.49
ADORA1 P30542 2/20 0.49
BCL6 P41182 1/20 0.46
KIF11 P52732 1/20 0.43
CYP19A1 P11511 1/20 0.43
MAPK1 P28482 1/20 0.41
APP P05067 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CDK5 Q00535 1/20 0.39
CDK5R1 Q15078 1/20 0.39
DPP4 P27487 1/20 0.39
MET P08581 1/20 0.39
DHFR P00374 1/20 0.39
IDH2 P48735 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoromethylbenzene SCHEMBL27850302 0.88 KDM4E (0.48) TSHRALDH1A1KDM4EADORA2AADORA1
Trifluoromethylbenzene SCHEMBL28051440 0.87 TSHR (0.67) TSHRALDH1A1KDM4EADORA2AADORA1
Trifluoromethylbenzene SCHEMBL28051441 0.84 TSHR (0.56) TSHRALDH1A1KDM4EADORA2AADORA1
Trifluoromethylbenzene SCHEMBL28051499 0.84 KDM4E (0.58) TSHRALDH1A1KDM4EADORA2AADORA1
SCHEMBL29807851 0.79 KDM4E (0.43) TSHRALDH1A1KDM4EADORA2AADORA1
Benzene SCHEMBL29138620 0.78 BCL6 (0.52) KDM4EADORA2AADORA1BCL6
Biphenyl SCHEMBL27987857 0.76 ADORA2A (0.56) ALDH1A1KDM4EADORA2AADORA1BCL6
Aniline SCHEMBL28021586 0.76 TSHR (0.55) TSHRKDM4EADORA2AADORA1BCL6
Trifluoromethylbenzene SCHEMBL28143223 0.75 TSHR (0.88) TSHRALDH1A1KIF11CYP19A1MAPK1
Trifluoromethylbenzene SCHEMBL8692 0.75 TSHR (1.00) TSHRALDH1A1KIF11CYP19A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103254144-B A kind of cyanuric chloride derivant and its preparation method and application WUHAN INSTITUTE OF TECHNOLOGY (CN) 2015-10-28 CN claimed
CN-103254144-B A kind of cyanuric chloride derivant and its preparation method and application WUHAN INSTITUTE OF TECHNOLOGY (CN) 2015-10-28 CN disclosed
CN-103254144-B A kind of cyanuric chloride derivant and its preparation method and application WUHAN INSTITUTE OF TECHNOLOGY (CN) 2015-10-28 CN disclosed