Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPY2R | P49146 | 2/20 | 0.46 |
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30642264 | 0.95 | POLB (0.50) | POLBMEN1KMT2ANPY2RSUV39H2 | |
| SCHEMBL16099091 | 0.95 | POLB (0.50) | POLBMEN1KMT2ANPY2RSUV39H2 | |
| SCHEMBL20139289 | 0.87 | MEN1 (0.47) | POLBMEN1KMT2ACFTRALDH1A1 | |
| SCHEMBL16117954 | 0.86 | POLB (0.53) | POLBMEN1KMT2ANPY2RSUV39H2 | |
| SCHEMBL30642272 | 0.81 | POLB (0.54) | POLBMEN1KMT2ANPY2RSUV39H2 | |
| SCHEMBL16117937 | 0.81 | POLB (0.54) | POLBMEN1KMT2ANPY2RSUV39H2 | |
| SCHEMBL16117821 | 0.81 | MEN1 (0.48) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL30642305 | 0.81 | MEN1 (0.48) | MEN1KMT2AALDH1A1HPGDNPC1 | |
| SCHEMBL29613213 | 0.81 | POLB (0.49) | POLBMEN1KMT2ANPY2RCFTR | |
| SCHEMBL16101994 | 0.79 | POLB (0.51) | POLBMEN1KMT2ANPY2RSUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189456-A | Covalent inhibitors of KRAS G12C | ARAXES PHARMA LLC | 2015-12-23 | — | — | CN | disclosed |