Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPY2R | P49146 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16117937 | 1.00 | POLB (0.54) | POLBNPY2RALDH1A1HPGDMEN1 | |
| SCHEMBL16099343 | 0.85 | ALDH1A1 (0.50) | POLBALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL26764213 | 0.85 | ALDH1A1 (0.62) | POLBALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL16101994 | 0.85 | POLB (0.51) | POLBNPY2RALDH1A1HPGDMEN1 | |
| SCHEMBL17643349 | 0.83 | ALDH1A1 (0.47) | POLBALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL16099940 | 0.83 | ALDH1A1 (0.47) | POLBALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL17643511 | 0.82 | RXFP1 (0.60) | POLBALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL16117954 | 0.81 | POLB (0.53) | POLBNPY2RALDH1A1HPGDMEN1 | |
| SCHEMBL28038271 | 0.81 | POLB (0.53) | POLBNPY2RALDH1A1HPGDMEN1 | |
| SCHEMBL1461421 | 0.80 | HTT (0.69) | POLBNPY2RALDH1A1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50527-E1 | Covalent inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2025-08-12 | — | — | US | disclosed |
| EP-3401314-B1 | COVALENT INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2023-11-08 | — | — | EP | disclosed |