Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 9/20 | 0.45 |
| ▸ | HTR2A | P28223 | 9/20 | 0.45 |
| ▸ | DRD3 | P35462 | 9/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15971536 | 0.86 | HTR2C (0.73) | HTR2CPHGDHDRD2HTR2ADRD3 | |
| SCHEMBL15971496 | 0.85 | HTR2C (0.71) | HTR2CPHGDHDRD2HTR2ADRD3 | |
| SCHEMBL4935508 | 0.83 | HTR2C (0.69) | HTR2CPHGDHDRD2HTR2ADRD3 | |
| SCHEMBL3679735 | 0.83 | HTR2C (0.69) | HTR2CPHGDHDRD2HTR2ADRD3 | |
| SCHEMBL1601087 | 0.83 | HTR2C (0.69) | HTR2CPHGDHDRD2HTR2ADRD3 | |
| SCHEMBL1026755 | 0.82 | HTR2C (1.00) | HTR2C | |
| SCHEMBL30297584 | 0.82 | HTR2C (1.00) | HTR2C | |
| SCHEMBL15971545 | 0.80 | HTR2C (0.64) | HTR2CPHGDHDRD2HTR2ADRD3 | |
| SCHEMBL15911226 | 0.79 | DRD2 (0.66) | DRD2HTR2ADRD3 | |
| SCHEMBL14983624 | 0.78 | HTR2C (0.62) | HTR2CPHGDHDRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143227-A | Substituted imidazo [1,2-B ] pyridazines as MKNK1 inhibitors | Bayer Pharma AG | 2015-12-09 | — | — | CN | disclosed |