Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27622821 | 0.91 | ALDH1A1 (0.58) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL7440960 | 0.91 | ALDH1A1 (0.47) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL9359181 | 0.89 | ALDH1A1 (0.46) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL31709800 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL2793142 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL27543987 | 0.87 | ALDH1A1 (0.50) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL25670038 | 0.86 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL958928 | 0.85 | ALDH1A1 (0.66) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL13248936 | 0.85 | ALDH1A1 (0.66) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 | |
| SCHEMBL25998487 | 0.85 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1TDP1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105440032-B | Pyrazines derivatives as ENAC blocking agents | 诺华股份有限公司 | 2017-12-08 | — | — | CN | disclosed |
| CN-105440032-A | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG | 2016-03-30 | — | — | CN | disclosed |
| CN-103249723-B | Pyrazine derivatives as ENAC blockers | NOVARTIS AG (CH) | 2015-11-25 | — | — | CN | disclosed |