Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL781984 | 0.96 | APP (0.59) | APPTDP1CA2CA1HSD17B2 | |
| SCHEMBL305392 | 0.86 | TDP1 (0.68) | APPTDP1LMNAMAPK1L3MBTL1 | |
| SCHEMBL197805 | 0.84 | APP (0.76) | APPTDP1MAPTMAPK1L3MBTL1 | |
| SCHEMBL14793687 | 0.82 | ALDH1A1 (0.63) | TDP1CA2CA1HSD17B2MAPK1 | |
| SCHEMBL28450115 | 0.81 | TDP1 (0.64) | APPTDP1MEN1KMT2AMAPT | |
| SCHEMBL304176 | 0.80 | TDP1 (0.78) | APPTDP1LMNAKMT2AMAPT | |
| SCHEMBL23086060 | 0.79 | APP (0.58) | APPTDP1MAPK1L3MBTL1POLB | |
| Ammonia Solution, Strong SCHEMBL28588274 | 0.79 | TDP1 (0.75) | APPTDP1LMNAKMT2AMAPT | |
| Bicarbonate SCHEMBL7699565 | 0.79 | TDP1 (0.75) | APPTDP1LMNAKMT2AMAPT | |
| SCHEMBL28207503 | 0.79 | TDP1 (0.75) | APPTDP1LMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105440032-A | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG | 2016-03-30 | — | — | CN | disclosed |
| CN-103249723-B | Pyrazine derivatives as ENAC blockers | NOVARTIS AG (CH) | 2015-11-25 | — | — | CN | disclosed |