Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | CFTR | P13569 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13011553 | 0.90 | P2RX4 (0.61) | HDAC6HDAC1HDAC10S1PR3HDAC3 | |
| SCHEMBL13011224 | 0.90 | CNR2 (0.55) | HDAC6HDAC1HDAC10S1PR3HDAC3 | |
| SCHEMBL13011250 | 0.88 | MAPT (0.53) | HDAC6HDAC1MAPTALDH1A1THRB | |
| SCHEMBL13011336 | 0.88 | MAPT (0.51) | HDAC6HDAC1HDAC10S1PR3HDAC3 | |
| SCHEMBL1002975 | 0.88 | HDAC6 (0.67) | HDAC6HDAC1HDAC10CYP19A1HDAC3 | |
| SCHEMBL13011169 | 0.87 | CNR2 (0.58) | HDAC6S1PR3HDAC3ALDH1A1CNR2 | |
| SCHEMBL13011342 | 0.86 | HTT (0.52) | HDAC6HDAC1HDAC10MAPTALDH1A1 | |
| SCHEMBL13011271 | 0.85 | ROCK2 (0.51) | HDAC6HDAC1HDAC10S1PR3HDAC3 | |
| SCHEMBL8388868 | 0.85 | CYP19A1 (0.60) | HDAC6HDAC1HDAC10CYP19A1HDAC3 | |
| SCHEMBL28039674 | 0.85 | CYP19A1 (0.64) | HDAC6HDAC1HDAC10CYP19A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008352-A | Carbazole compounds useful as bromodomain inhibitors | BRISTOL MYERS SQUIBB CO | 2015-10-28 | — | — | CN | disclosed |