Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LDHB | P07195 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28041187 | 0.89 | SYK (0.47) | SYKHPGDNPC1RAB9ALDHA | |
| SCHEMBL27868874 | 0.85 | HPGD (0.46) | SYKHPGDNPC1RAB9ALDHA | |
| SCHEMBL27868871 | 0.83 | HPGD (0.45) | HPGDNPC1RAB9ALDHALDHB | |
| SCHEMBL1458828 | 0.77 | HPGD (0.52) | SYKHPGDADORA2AADORA1NPC1 | |
| SCHEMBL9949901 | 0.77 | HPGD (0.52) | SYKHPGDADORA2AADORA1NPC1 | |
| SCHEMBL27885415 | 0.77 | HPGD (0.56) | HPGDJAK2JAK3 | |
| SCHEMBL27868880 | 0.75 | CHEK1 (0.52) | HPGDNPC1RAB9AJAK2JAK3 | |
| SCHEMBL2277781 | 0.74 | SYK (0.52) | SYKJAK2JAK3 | |
| SCHEMBL27868895 | 0.74 | NEK2 (0.41) | HPGDADORA2ANPC1RAB9AJAK2 | |
| SCHEMBL27868873 | 0.73 | ABCG2 (0.53) | HPGDJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102656163-B | Suppress the heterogeneous ring compound of PASK | BIOENERGENIX (US) | 2016-01-13 | — | — | CN | claimed |
| CN-102656163-B | Suppress the heterogeneous ring compound of PASK | BIOENERGENIX (US) | 2016-01-13 | — | — | CN | disclosed |