Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | LDHA | P00338 | 2/20 | 0.43 |
| ▸ | LDHB | P07195 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28041311 | 0.89 | SYK (0.49) | SYKHPGDLDHALDHBJAK3 | |
| SCHEMBL27868874 | 0.87 | HPGD (0.46) | SYKHPGDLDHALDHBJAK3 | |
| SCHEMBL27868871 | 0.86 | HPGD (0.45) | HPGDLDHALDHBJAK3JAK2 | |
| SCHEMBL27885415 | 0.80 | HPGD (0.56) | HPGDJAK3JAK2MAPK1 | |
| SCHEMBL12401317 | 0.79 | MAPK1 (0.48) | SYKJAK3JAK2IRAK4MAPK1 | |
| SCHEMBL27868872 | 0.76 | KMO (0.57) | HPGDJAK3JAK2PIK3CA | |
| SCHEMBL27868880 | 0.76 | CHEK1 (0.52) | HPGDJAK3JAK2NPC1RAB9A | |
| SCHEMBL27868873 | 0.76 | ABCG2 (0.53) | HPGDJAK3JAK2 | |
| SCHEMBL1457983 | 0.75 | HPGD (0.55) | HPGDNPC1RAB9A | |
| SCHEMBL1459881 | 0.75 | HPGD (0.55) | HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102656163-B | Suppress the heterogeneous ring compound of PASK | BIOENERGENIX (US) | 2016-01-13 | — | — | CN | claimed |
| CN-102656163-B | Suppress the heterogeneous ring compound of PASK | BIOENERGENIX (US) | 2016-01-13 | — | — | CN | disclosed |