Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28042545 | 0.85 | PDE10A (0.68) | PDE10AJAK2DHFRMAPTMKNK1 | |
| SCHEMBL28042544 | 0.84 | PDE10A (0.45) | PDE10A | |
| SCHEMBL15905044 | 0.74 | PDE10A (1.00) | PDE10A | |
| SCHEMBL15904927 | 0.72 | PDE10A (0.78) | PDE10AMKNK1 | |
| SCHEMBL28042559 | 0.69 | PDE10A (0.58) | PDE10AMAPT | |
| SCHEMBL28245414 | 0.68 | PDE10A (0.46) | PDE10AMAPTMKNK1 | |
| SCHEMBL15904970 | 0.67 | PDE10A (1.00) | PDE10A | |
| SCHEMBL15905011 | 0.67 | PDE10A (0.74) | PDE10A | |
| SCHEMBL2550404 | 0.67 | ADORA2A (0.53) | PDE10AMAPT | |
| SCHEMBL15904142 | 0.65 | PDE10A (0.81) | PDE10AMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | claimed |
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | disclosed |