Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28042324 | 0.85 | PDE10A (0.59) | PDE10AJAK2DHFRMKNK1MAPT | |
| SCHEMBL15905044 | 0.81 | PDE10A (1.00) | PDE10AADORA2A | |
| SCHEMBL28042347 | 0.77 | EGLN1 (0.45) | PDE10ADHFRMAPTADORA2A | |
| SCHEMBL15904142 | 0.72 | PDE10A (0.81) | PDE10AMKNK1ADORA2AMKNK2 | |
| SCHEMBL28042503 | 0.71 | PDE10A (0.68) | PDE10ACYP2D6JAK2MKNK1DYRK1B | |
| SCHEMBL15904927 | 0.71 | PDE10A (0.78) | PDE10AMKNK1ADORA2A | |
| SCHEMBL28245414 | 0.70 | PDE10A (0.46) | PDE10ACYP2D6MKNK1MAPTDYRK1B | |
| SCHEMBL12203764 | 0.70 | PDE10A (0.46) | PDE10ACYP2D6MKNK1MAPTDYRK1B | |
| SCHEMBL15904251 | 0.69 | PDE10A (0.74) | PDE10AMKNK1ADORA2A | |
| SCHEMBL5218758 | 0.69 | PDE10A (0.46) | PDE10ACYP2D6JAK2GSK3BMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | claimed |
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | disclosed |