Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.59 |
| ▸ | PDE4A | P27815 | 11/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2541912 | 0.76 | ADORA2A (0.59) | PDE10AADORA2ALMNAADORA1 | |
| SCHEMBL15905211 | 0.74 | PDE10A (1.00) | PDE10APDE4AADORA2A | |
| SCHEMBL28042559 | 0.74 | PDE10A (0.58) | PDE10APDE4AADORA2APDE4BKDM4E | |
| SCHEMBL28042501 | 0.72 | PDE10A (0.46) | PDE10APDE4AADORA2APDE4BKDM4E | |
| SCHEMBL4988262 | 0.66 | PDE10A (0.41) | PDE10APDE4APDE4B | |
| SCHEMBL17484749 | 0.62 | LMNA (0.38) | PDE10APDE4AADORA2APDE4BKDM4E | |
| Pbf-999 SCHEMBL15905362 | 0.61 | PDE10A (1.00) | PDE10APDE4AADORA2APDE4B | |
| SCHEMBL15903915 | 0.61 | ADORA2A (0.76) | PDE10AADORA2AADORA1 | |
| SCHEMBL12874454 | 0.61 | PDE10A (0.43) | PDE10APDE4APDE4BKDM4ETSHR | |
| SCHEMBL21640528 | 0.60 | PDE10A (0.38) | PDE10APDE4AADORA2APDE4BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | claimed |
| CN-105008346-B | Pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | 帕罗生物制药有限公司 | 2018-11-13 | — | — | CN | disclosed |
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | disclosed |