Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15904142 | 0.85 | PDE10A (0.81) | PDE10AADORA3ADORA1ADORA2AMKNK1 | |
| SCHEMBL15905044 | 0.81 | PDE10A (1.00) | PDE10AADORA3ADORA1ADORA2A | |
| SCHEMBL15904927 | 0.79 | PDE10A (0.78) | PDE10AADORA3ADORA1ADORA2AMKNK1 | |
| SCHEMBL15904251 | 0.77 | PDE10A (0.74) | PDE10AADORA3ADORA1ADORA2AMKNK1 | |
| SCHEMBL15905378 | 0.74 | PDE10A (0.68) | PDE10AADORA3ADORA1ADORA2AMKNK1 | |
| SCHEMBL15904999 | 0.72 | PDE10A (1.00) | PDE10AADORA3ADORA1ADORA2AMKNK1 | |
| SCHEMBL28042545 | 0.71 | PDE10A (0.68) | PDE10AADORA2AMKNK1JAK2MKNK2 | |
| SCHEMBL15905349 | 0.71 | PDE10A (0.66) | PDE10AADORA3ADORA1ADORA2AMKNK1 | |
| SCHEMBL15904941 | 0.70 | PDE10A (0.62) | PDE10AADORA3ADORA1ADORA2AMKNK1 | |
| SCHEMBL5218142 | 0.70 | PDE10A (0.42) | PDE10AMKNK1JAK2MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | disclosed |