Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.48 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.48 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5558505 | 0.79 | ALDH1A1 (0.52) | CA12CA1CA2CA9CDK8 | |
| SCHEMBL5562183 | 0.78 | CDK8 (0.54) | CA12CA1CA2CA9CDK8 | |
| SCHEMBL26114637 | 0.78 | CA12 (0.52) | CA12CA1CA2CA9CDK8 | |
| SCHEMBL5558179 | 0.77 | CDK8 (0.56) | CA12CA1CA2CA9TGFBR1 | |
| SCHEMBL27379231 | 0.77 | CA12 (0.51) | CA12CA1CA2CA9CDK8 | |
| SCHEMBL67941 | 0.77 | CA12 (0.68) | CA12CA1CA2CA9CDK8 | |
| SCHEMBL12777036 | 0.76 | CA12 (0.60) | CA12CA1CA2CA9CDK8 | |
| SCHEMBL30350436 | 0.76 | CA12 (0.60) | CA12CA1CA2CA9CDK8 | |
| SCHEMBL1745570 | 0.76 | CA12 (0.50) | CA12CA1CA2CA9CDK8 | |
| SCHEMBL5562972 | 0.76 | ABL1 (0.58) | CA12CA1CA2CA9CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105073751-B | The substituted imidazoles new as Casein kinase 1 δ/epsilon inhibitor | 百时美施贵宝公司 | 2018-11-30 | — | — | CN | disclosed |
| CN-105073751-A | Novel substituted imidazoles as casein kinase 1 [delta]/[epsilon] inhibitors | BRISTOL MYERS SQUIBB CO | 2015-11-18 | — | — | CN | disclosed |