Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777106 | 0.79 | P2RX7 (0.47) | P2RX7PTGDR2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL4362725 | 0.79 | PTGDR2 (0.38) | P2RX7PTGDR2ALDH1A1KDM4EMAPT | |
| SCHEMBL4361450 | 0.78 | P2RX7 (0.51) | P2RX7ALDH1A1MAPTHPGD | |
| SCHEMBL16156183 | 0.78 | MEN1 (0.38) | ALDH1A1MAPTHPGD | |
| SCHEMBL24044109 | 0.76 | MAPK1 (0.39) | P2RX7PTGDR2ALDH1A1KDM4EMAPT | |
| SCHEMBL2594257 | 0.76 | — | — | |
| SCHEMBL12806714 | 0.74 | — | — | |
| SCHEMBL4359176 | 0.74 | POLB (0.39) | ALDH1A1KDM4EMAPTMAPK1HPGD | |
| SCHEMBL24664567 | 0.74 | PTGDR2 (0.33) | P2RX7PTGDR2AGBL2LPAR1 | |
| SCHEMBL5410258 | 0.73 | GAA (0.48) | KDM4EL3MBTL1HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143203-A | N-piperidin-3-ylbenzamide derivatives for the treatment of cardiovascular diseases | PFIZER | 2015-12-09 | — | — | CN | disclosed |