Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Conivaptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 known ✓ | P30518 | 16/20 | 0.98 |
| ▸ | AVPR1A known ✓ | P37288 | 13/20 | 0.98 |
| ▸ | OXTR | P30559 | 1/20 | 0.58 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Conivaptan SCHEMBL49815 | 0.99 | AVPR2 (1.00) | AVPR2AVPR1AOXTRAVPR1B | |
| Conivaptan SCHEMBL1649913 | 0.97 | AVPR2 (0.97) | AVPR2AVPR1AOXTRAVPR1B | |
| Conivaptan SCHEMBL387232 | 0.86 | AVPR2 (0.74) | AVPR2AVPR1AOXTRAVPR1B | |
| Hydrochloric Acid SCHEMBL6993733 | 0.85 | AVPR2 (0.73) | AVPR2AVPR1AOXTRAVPR1B | |
| Conivaptan SCHEMBL29406590 | 0.85 | AVPR2 (0.75) | AVPR2AVPR1AOXTRAVPR1B | |
| Conivaptan SCHEMBL4625101 | 0.85 | AVPR2 (0.75) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL8204092 | 0.84 | AVPR2 (0.74) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL6991859 | 0.83 | AVPR1A (0.72) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL17471526 | 0.83 | AVPR2 (0.72) | AVPR2AVPR1AOXTRAVPR1B | |
| SCHEMBL11929158 | 0.82 | AVPR1A (0.71) | AVPR2AVPR1AOXTRAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153168-A | Preparation method of N-[4-(2-methyl-4,5-dihydro-3H-imidazo [4,5-d] [1] benzazepin-6-formyl) phenyl]-2-phenylbenzamide hydrochloride | SHANGHAI TIANCI INTERNAT PHARMACEUTICAL CO LTD | 2015-12-16 | — | — | CN | disclosed |
| CN-105153168-A | Preparation method of N-[4-(2-methyl-4,5-dihydro-3H-imidazo [4,5-d] [1] benzazepin-6-formyl) phenyl]-2-phenylbenzamide hydrochloride | SHANGHAI TIANCI INTERNAT PHARMACEUTICAL CO LTD | 2015-12-16 | — | — | CN | disclosed |