Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575031 | 0.92 | BRAF (0.36) | BRAFEGFRMAPK8MAPK9MAPK10 | |
| SCHEMBL574904 | 0.92 | BRAF (0.38) | BRAFEGFRMAPK8MAPK9MAPK10 | |
| SCHEMBL574445 | 0.91 | BRAF (0.36) | BRAFEGFR | |
| SCHEMBL28043500 | 0.91 | EGFR (0.38) | BRAFEGFR | |
| SCHEMBL15191846 | 0.90 | BRAF (0.35) | BRAFEGFRMAPK8MAPK9MAPK10 | |
| SCHEMBL15191461 | 0.90 | BRAF (0.35) | BRAFEGFRMAPK8MAPK9MAPK10 | |
| SCHEMBL28043303 | 0.86 | BRAF (0.35) | BRAFMAPK14 | |
| SCHEMBL15191754 | 0.84 | BRAF (0.38) | BRAFMAPK8MAPK9MAPK10 | |
| SCHEMBL15192242 | 0.83 | EGFR (0.36) | BRAFEGFR | |
| SCHEMBL574377 | 0.83 | MAPK8 (0.35) | BRAFMAPK8MAPK9MAPK10PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103153980-B | Derivatives of pyrazolophenylbenzenesulfonamide compounds and their use as antitumor agents | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-16 | — | — | CN | disclosed |