Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | BMX | P51813 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28043516 | 0.91 | BRAF (0.36) | EGFRBRAF | |
| SCHEMBL574504 | 0.90 | EGFR (0.37) | EGFRBRAF | |
| SCHEMBL15191744 | 0.90 | EGFR (0.41) | EGFRBTK | |
| SCHEMBL15192202 | 0.90 | EGFR (0.42) | EGFRBRAFERBB2BMXBTK | |
| SCHEMBL15191983 | 0.90 | EGFR (0.38) | EGFRBRAFMAPK3MAPK1 | |
| SCHEMBL575019 | 0.87 | KDM1A (0.37) | EGFRBRAFMAPK3MAPK1 | |
| SCHEMBL15192073 | 0.87 | BRAF (0.36) | EGFRBRAFMAPK3MAPK1 | |
| SCHEMBL28043303 | 0.86 | BRAF (0.35) | BRAF | |
| SCHEMBL15192242 | 0.83 | EGFR (0.36) | EGFRBRAF | |
| SCHEMBL574508 | 0.82 | GPR119 (0.36) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103153980-B | Derivatives of pyrazolophenylbenzenesulfonamide compounds and their use as antitumor agents | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-16 | — | — | CN | disclosed |