Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 6/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28213045 | 0.81 | TSHR (0.38) | TSHRESR2GAAPOLBPDK2 | |
| SCHEMBL28813910 | 0.79 | GAA (0.37) | TSHRESR2L3MBTL1GAAKDM4E | |
| SCHEMBL11608 | 0.77 | TSHR (0.50) | TSHRESR2L3MBTL1GAAPOLB | |
| SCHEMBL29468918 | 0.77 | TSHR (0.50) | TSHRESR2L3MBTL1GAAPOLB | |
| SCHEMBL18411232 | 0.77 | GAA (0.43) | TSHRL3MBTL1GAAPOLBKDM4E | |
| SCHEMBL840396 | 0.77 | GAA (0.36) | TSHRESR2L3MBTL1GAAKDM4E | |
| SCHEMBL1138569 | 0.75 | ESR2 (0.35) | TSHRESR2L3MBTL1GAAKDM4E | |
| SCHEMBL16276509 | 0.74 | TSHR (0.46) | TSHRESR2L3MBTL1GAAPOLB | |
| SCHEMBL840344 | 0.73 | TSHR (0.35) | TSHRESR2GAAPOLBPDK2 | |
| SCHEMBL9894281 | 0.73 | GAA (0.33) | TSHRESR2L3MBTL1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164513-A | Substituted oxo pyridine derivative and its purposes in terms of cardiovascular disorder is treated | 拜耳制药股份公司 | 2018-06-15 | — | — | CN | disclosed |
| CN-105555767-B | Substituted oxo pyridine derivative and its purposes as factor XI, plasma thromboplastin antecedent A/ blood plasma | 拜耳制药股份公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-105164122-B | Substituted oxopyridine derivatives and their use in the treatment of cardiovascular disorders | 拜耳制药股份公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-105849109-B | Substituted oxopyridine derivatives | 拜耳制药股份公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-106687458-A | Substituted oxopyridine derivatives | 拜耳制药股份公司 | 2017-05-17 | — | — | CN | disclosed |
| CN-103958487-B | Benzoic acid derivative as EIF4E inhibitor | 霍夫曼-拉罗奇有限公司 | 2016-07-13 | — | — | CN | disclosed |
| CN-105555767-A | Substituted oxopyridine derivatives and use thereof as factor XIA/plasma | Bayer Pharma AG | 2016-05-04 | — | — | CN | disclosed |
| CN-105164122-A | Substituted oxopyridine derivatives and their use in the treatment of cardiovascular disorders | Bayer Pharma AG | 2015-12-16 | — | — | CN | disclosed |