Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 18/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15757013 | 0.82 | HRH4 (0.56) | HRH4HRH3 | |
| SCHEMBL15521589 | 0.78 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL13650797 | 0.78 | HRH4 (0.55) | HRH4HRH3HRH1 | |
| SCHEMBL28151194 | 0.78 | NPC1 (0.49) | HRH4 | |
| SCHEMBL28043938 | 0.76 | PTGS2 (0.54) | — | |
| SCHEMBL28152251 | 0.76 | CA1 (0.55) | — | |
| SCHEMBL15521620 | 0.73 | HRH4 (0.82) | HRH4HRH3 | |
| SCHEMBL4390821 | 0.72 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL28151149 | 0.72 | HRH4 (0.64) | HRH4 | |
| SCHEMBL2166970 | 0.71 | HRH4 (1.00) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |
| CN-105143206-A | Pyrimidine-2,4-diamine derivatives for treatment of cancer | THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING | 2015-12-09 | — | — | CN | disclosed |