Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Phosphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28054108 | 0.98 | HIF1A (0.46) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 | |
| Bromide SCHEMBL161017 | 0.98 | HIF1A (0.50) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 | |
| Iodide SCHEMBL28057254 | 0.93 | HIF1A (0.46) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 | |
| Iodide SCHEMBL1054412 | 0.93 | HIF1A (0.50) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 | |
| Water SCHEMBL3422252 | 0.93 | HIF1A (0.50) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL477383 | 0.93 | HIF1A (0.50) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 | |
| SCHEMBL9180560 | 0.87 | HIF1A (0.44) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 | |
| SCHEMBL28131525 | 0.87 | HIF1A (0.44) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 | |
| Perchlorate SCHEMBL11848103 | 0.87 | HIF1A (0.44) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 | |
| SCHEMBL8972925 | 0.87 | HIF1A (0.44) | HIF1ACYP2C19TSHRALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109735347-A | It is a kind of anti-, trans- 4- phenyl -4 '-amyl -3(E) alkene-dicyclic hexane liquid crystal monomer preparation method | 中节能万润股份有限公司 | 2019-05-10 | — | — | CN | claimed |
| CN-104403250-B | A kind of polymethyl methacrylate resin of excellent heat stability | 上海金山锦湖日丽塑料有限公司 | 2016-09-14 | — | — | CN | claimed |
| CN-105477633-B | A kind of hypocrellin cationic liposomal formulation and the preparation method and application thereof | 中国人民解放军总医院第一附属医院 | 2019-06-11 | — | — | CN | disclosed |
| CN-109735347-A | It is a kind of anti-, trans- 4- phenyl -4 '-amyl -3(E) alkene-dicyclic hexane liquid crystal monomer preparation method | 中节能万润股份有限公司 | 2019-05-10 | — | — | CN | disclosed |
| CN-105130933-B | A kind of method for preparing 3 substitution coumarans | 苏州大学 | 2017-10-10 | — | — | CN | disclosed |
| CN-105130933-A | Method for preparing 3-substituted dihydrobenzofuran | UNIV SOOCHOW | 2015-12-09 | — | — | CN | disclosed |