Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 10/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | ADCY10 | Q96PN6 | 5/20 | 0.42 |
| ▸ | HEXA | P06865 | 1/20 | 0.41 |
| ▸ | HEXB | P07686 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451558 | 0.83 | HSP90AB1 (0.68) | HSP90AB1HSP90AA1KDM4EHRH4KMT2A | |
| SCHEMBL1357541 | 0.80 | AURKA (0.49) | HSP90AB1HSP90AA1HRH4HEXAHEXB | |
| SCHEMBL5104693 | 0.80 | HSP90AB1 (0.63) | HSP90AB1HSP90AA1KDM4EHRH4ADCY10 | |
| SCHEMBL28152268 | 0.80 | DYRK1A (0.53) | HEXAHEXBKMT2AADORA2AADORA1 | |
| SCHEMBL14413753 | 0.78 | HSP90AA1 (0.72) | HSP90AB1HSP90AA1KDM4EHRH4KMT2A | |
| Ammonia Solution, Strong SCHEMBL5567629 | 0.78 | HSP90AA1 (0.51) | HSP90AB1HSP90AA1KDM4EADCY10KMT2A | |
| SCHEMBL1643108 | 0.74 | HSP90AA1 (1.00) | HSP90AB1HSP90AA1KDM4EHRH4KMT2A | |
| SCHEMBL3951575 | 0.74 | HSP90AB1 (0.72) | HSP90AB1HSP90AA1KDM4EHRH4ADCY10 | |
| SCHEMBL27460747 | 0.74 | HSP90AA1 (0.71) | HSP90AB1HSP90AA1KDM4EHRH4KMT2A | |
| SCHEMBL28043765 | 0.74 | NUDT1 (0.53) | HRH4HEXAHEXB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |
| CN-105143206-A | Pyrimidine-2,4-diamine derivatives for treatment of cancer | THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING | 2015-12-09 | — | — | CN | disclosed |