SCHEMBL28043925

SCHEMBL28043925

COc1c(-c2cc(Cl)nc(N)n2)ccc(Cl)c1Cl

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 14/20 0.63
HSP90AB1 P08238 12/20 0.63
KDM4E B2RXH2 1/20 0.44
NUDT1 P36639 1/20 0.42
MAPT P10636 2/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
ADCY10 Q96PN6 2/20 0.39
CDC7 O00311 1/20 0.39
DAPK3 O43293 1/20 0.39
PRKD3 O94806 1/20 0.39
MAP4K4 O95819 1/20 0.39
PAK4 O96013 1/20 0.39
PIM1 P11309 1/20 0.39
PRKACA P17612 1/20 0.39
GRK5 P34947 1/20 0.39
MAP2K2 P36507 1/20 0.39
MAPK8 P45983 1/20 0.39
CSNK1A1 P48729 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28043978 0.83 NUDT1 (0.64) HSP90AA1HSP90AB1NUDT1ROCK1
SCHEMBL15757653 0.82 HSP90AA1 (0.67) HSP90AA1HSP90AB1KDM4ENUDT1CDC7
SCHEMBL3942360 0.78 HSP90AA1 (0.76) HSP90AA1HSP90AB1KDM4EGAAADCY10
SCHEMBL3945098 0.78 HSP90AA1 (1.00) HSP90AA1HSP90AB1KDM4EMAPTPOLB
SCHEMBL3946976 0.78 HSP90AA1 (1.00) HSP90AA1HSP90AB1KDM4EMAPTPOLB
SCHEMBL15757594 0.75 HSP90AA1 (0.69) HSP90AA1HSP90AB1KDM4ENUDT1MAPT
SCHEMBL30401919 0.74 HSP90AA1 (0.58) HSP90AA1HSP90AB1KDM4EADCY10CDC7
SCHEMBL20400253 0.74 HSP90AA1 (0.58) HSP90AA1HSP90AB1KDM4EADCY10CDC7
SCHEMBL3952031 0.73 HSP90AA1 (0.78) HSP90AA1HSP90AB1KDM4ENUDT1MAPT
SCHEMBL4281168 0.73 HSP90AA1 (0.75) HSP90AA1HSP90AB1KDM4ENUDT1ADCY10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105143206-A Pyrimidine-2,4-diamine derivatives for treatment of cancer THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING 2015-12-09 CN disclosed