Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28151084 | 0.99 | HRH4 (0.55) | HRH4TLR8HRH3AURKAJAK1 | |
| SCHEMBL28043727 | 0.94 | HRH4 (0.56) | HRH4TLR8HRH3AURKASYK | |
| SCHEMBL28151149 | 0.90 | HRH4 (0.64) | HRH4TLR8AURKAAURKB | |
| SCHEMBL28043930 | 0.89 | HRH4 (0.55) | HRH4TLR8AURKAAURKB | |
| SCHEMBL28267199 | 0.88 | TLR8 (0.65) | HRH4TLR8AURKAAURKB | |
| SCHEMBL28152094 | 0.85 | HRH4 (0.54) | HRH4TLR8AURKAAURKB | |
| SCHEMBL28845266 | 0.82 | CYP2D6 (0.55) | HRH4TLR8AURKAAURKB | |
| SCHEMBL28267608 | 0.81 | TLR8 (0.50) | HRH4TLR8HRH3AURKAAURKB | |
| SCHEMBL28267189 | 0.81 | TLR8 (0.53) | HRH4TLR8AURKAAURKB | |
| SCHEMBL28845271 | 0.80 | HRH4 (0.72) | HRH4TLR8HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |
| CN-105143206-A | Pyrimidine-2,4-diamine derivatives for treatment of cancer | THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING | 2015-12-09 | — | — | CN | disclosed |