Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | DNM2 | P50570 | 6/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28151084 | 0.89 | HRH4 (0.55) | TLR8HRH4AURKAPDPK1TGFBR1 | |
| SCHEMBL28151149 | 0.88 | HRH4 (0.64) | TLR8HRH4AURKAPDPK1TGFBR1 | |
| SCHEMBL28043961 | 0.88 | HRH4 (0.54) | TLR8HRH4AURKAAURKB | |
| SCHEMBL28043727 | 0.87 | HRH4 (0.56) | TLR8HRH4AURKAPDPK1TGFBR1 | |
| SCHEMBL28043930 | 0.84 | HRH4 (0.55) | TLR8HRH4AURKAPDPK1TGFBR1 | |
| SCHEMBL28043772 | 0.84 | AURKA (0.54) | TLR8HRH4AURKAPDPK1TGFBR1 | |
| SCHEMBL28152094 | 0.83 | HRH4 (0.54) | TLR8HRH4AURKAPDPK1TGFBR1 | |
| SCHEMBL28845266 | 0.83 | CYP2D6 (0.55) | TLR8HRH4AURKAPDPK1TGFBR1 | |
| SCHEMBL28267189 | 0.82 | TLR8 (0.53) | TLR8HRH4AURKAPDPK1TGFBR1 | |
| SCHEMBL28267608 | 0.82 | TLR8 (0.50) | TLR8HRH4AURKAPDPK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |