Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | LIPE | Q05469 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28044588 | 0.73 | NR1H2 (0.44) | NR1H2LIPERORCJAK1USP30 | |
| SCHEMBL23794846 | 0.70 | PARP1 (0.44) | NR1H2KDM4E | |
| SCHEMBL5938643 | 0.70 | NR1H2 (0.54) | NR1H2LIPERORCUSP30DDB1 | |
| SCHEMBL5940329 | 0.70 | NR1H2 (0.54) | NR1H2LIPERORCUSP30DDB1 | |
| SCHEMBL28044510 | 0.66 | USP30 (0.42) | NR1H2LIPERORCJAK1USP30 | |
| SCHEMBL15634408 | 0.66 | NR1H2 (0.51) | NR1H2LIPERORCUSP30DDB1 | |
| SCHEMBL2355843 | 0.65 | NR1H2 (0.49) | NR1H2LIPERORCUSP30DDB1 | |
| SCHEMBL19272699 | 0.65 | NR1H2 (0.49) | NR1H2LIPERORCUSP30DDB1 | |
| SCHEMBL15012086 | 0.65 | NR1H2 (0.49) | NR1H2LIPERORCUSP30DDB1 | |
| SCHEMBL19456156 | 0.65 | NR1H2 (0.74) | NR1H2JAK1DDB1CRBNGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085530-A | Fused tricyclic substituted amino six-membered ring derivative and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2015-11-25 | — | — | CN | disclosed |