Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28044510 | 0.77 | USP30 (0.42) | NR1H2USP30LIPERORCJAK1 | |
| SCHEMBL26124711 | 0.75 | KDM4E (0.46) | NR1H2KDM4EJAK1GPR119SPR | |
| SCHEMBL28044595 | 0.73 | NR1H2 (0.40) | NR1H2USP30LIPERORCKDM4E | |
| SCHEMBL5940329 | 0.73 | NR1H2 (0.54) | NR1H2USP30LIPERORCKDM4E | |
| SCHEMBL5938643 | 0.73 | NR1H2 (0.54) | NR1H2USP30LIPERORCKDM4E | |
| SCHEMBL24069346 | 0.70 | MEN1 (0.36) | NR1H2KDM4EJAK1GPR119MAPT | |
| SCHEMBL30403503 | 0.70 | MEN1 (0.36) | NR1H2KDM4EJAK1GPR119MAPT | |
| SCHEMBL31503237 | 0.70 | MAPK1 (0.47) | NR1H2USP30LIPERORCKDM4E | |
| SCHEMBL2344939 | 0.70 | NR1H2 (0.50) | NR1H2MAPT | |
| SCHEMBL31692475 | 0.69 | CHRM2 (0.43) | KDM4EJAK1GPR119MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085530-B | Ternary condenses cyclosubstituted amino hexatomic ring analog derivative and its application in medicine | 四川海思科制药有限公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-105085530-A | Fused tricyclic substituted amino six-membered ring derivative and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2015-11-25 | — | — | CN | disclosed |