Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.53 |
| ▸ | TTK | P33981 | 3/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.48 |
| ▸ | CDK2 | P24941 | 8/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.36 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27919681 | 0.88 | CCNA2 (0.44) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12694291 | 0.87 | PIM1 (0.61) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12694287 | 0.86 | PIM1 (0.72) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12694272 | 0.85 | PIM1 (0.59) | PIM1PIM2TTKCCNA2CDK2 | |
| Hydrochloric Acid SCHEMBL28044763 | 0.85 | PIM1 (0.70) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL28044740 | 0.76 | PIM1 (0.52) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL15364355 | 0.75 | CCNA2 (0.49) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12466424 | 0.75 | CCNA2 (0.57) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL9940453 | 0.74 | CDK2 (0.49) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12466309 | 0.73 | CCNA2 (0.50) | PIM1PIM2TTKCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103339134-B | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-23 | — | — | CN | disclosed |