Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.52 |
| ▸ | TTK | P33981 | 5/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 2/20 | 0.35 |
| ▸ | LITAF | Q99732 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466447 | 0.86 | PIM1 (0.60) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL12466396 | 0.86 | PIM1 (0.72) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL12694274 | 0.85 | PIM1 (0.59) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL9940743 | 0.77 | PIM1 (0.49) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL28044752 | 0.76 | PIM1 (0.53) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL12466428 | 0.75 | PIM1 (0.41) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL28044742 | 0.75 | PIM1 (0.47) | PIM1TTKPIM2 | |
| SCHEMBL20641778 | 0.74 | HCAR1 (0.41) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL11025920 | 0.72 | PIM1 (0.47) | PIM1TTKPIM2CCNA2CDK2 | |
| SCHEMBL20641795 | 0.72 | HCAR1 (0.46) | CCNA2CDK2HCAR1GPR119NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103339134-B | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-23 | — | — | CN | disclosed |