Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.40 |
| ▸ | TTK | P33981 | 6/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.34 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466634 | 0.80 | TET2 (0.47) | PIM1TTKPIM2TET2TET1 | |
| SCHEMBL12466284 | 0.79 | NR4A2 (0.46) | PIM1TTKPIM2 | |
| SCHEMBL12466645 | 0.78 | PIM1 (0.52) | PIM1TTKPIM2TET2TET1 | |
| SCHEMBL28824589 | 0.77 | PIM1 (0.39) | PIM1TTKPIM2HASPINNPC1 | |
| SCHEMBL28044742 | 0.75 | PIM1 (0.47) | PIM1TTKPIM2SLC22A6HASPIN | |
| SCHEMBL12466687 | 0.68 | PIM1 (0.47) | PIM1TTKPIM2HASPINNPC1 | |
| SCHEMBL9940611 | 0.68 | PIM1 (0.49) | PIM1TTKPIM2HASPINNPC1 | |
| SCHEMBL12466430 | 0.68 | PIM1 (0.56) | PIM1TTKPIM2HASPINNPC1 | |
| SCHEMBL12466601 | 0.67 | ALDH1A1 (0.44) | PIM1TTKPIM2NPC1RAB9A | |
| SCHEMBL9940993 | 0.67 | KDM4E (0.45) | PIM1TTKPIM2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103339134-B | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-23 | — | — | CN | disclosed |