Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.88 |
| ▸ | TYMP | P19971 | 1/20 | 0.56 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL849667 | 0.95 | MAPT (0.97) | MAPTTYMPCASP6ALDH1A1LMNA | |
| SCHEMBL28045491 | 0.94 | MAPT (1.00) | MAPTTYMPCASP6ALDH1A1LMNA | |
| SCHEMBL293278 | 0.84 | MAPT (0.68) | MAPTTYMPCASP6ALDH1A1LMNA | |
| SCHEMBL10725654 | 0.83 | MAPT (0.67) | MAPTTYMPCASP6ALDH1A1LMNA | |
| SCHEMBL292962 | 0.83 | MAPT (0.71) | MAPTTYMPCASP6ALDH1A1LMNA | |
| SCHEMBL28045624 | 0.83 | MAPT (0.67) | MAPTTYMPCASP6ALDH1A1LMNA | |
| SCHEMBL510088 | 0.81 | MAPT (0.74) | MAPTTYMPCASP6ALDH1A1LMNA | |
| SCHEMBL511169 | 0.80 | MAPT (0.63) | MAPTTYMPCASP6ALDH1A1L3MBTL1 | |
| SCHEMBL6605667 | 0.79 | MAPT (0.61) | MAPTTYMPCASP6L3MBTL1TDP1 | |
| SCHEMBL29594271 | 0.76 | LOXL2 (0.56) | MAPTLMNASMN1; SMN2L3MBTL1TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218506-B | A method of isocoumarin class compound is prepared by o-Halogen benzoic acids methyl esters and terminal alkyne | 湖南大学 | 2018-09-04 | — | — | CN | disclosed |
| CN-105218506-A | A kind of method being prepared Isocoumarin compounds by o-Halogen benzoic acids methyl esters and terminal alkyne | UNIV HUNAN | 2016-01-06 | — | — | CN | disclosed |