Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.47 |
| ▸ | CHRNG | P07510 | 2/20 | 0.47 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.47 |
| ▸ | CHRND | Q07001 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CTSC | P53634 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555734 | 0.86 | F2 (0.56) | ITGB3ITGA2BF2 | |
| SCHEMBL9350149 | 0.86 | CYP3A4 (0.53) | PSMB8PSMB5 | |
| SCHEMBL9728137 | 0.84 | HTT (0.51) | CNR2ITGB3ITGA2B | |
| SCHEMBL8177395 | 0.81 | HRH1 (0.43) | F2POLBPSMB5 | |
| SCHEMBL8177397 | 0.81 | HRH1 (0.43) | F2POLBPSMB5 | |
| SCHEMBL9132107 | 0.80 | CTSC (0.60) | CTSCMMP2 | |
| SCHEMBL2196618 | 0.80 | CTSC (0.60) | CTSCMMP2 | |
| SCHEMBL10633263 | 0.80 | CTSC (0.60) | CTSCMMP2 | |
| SCHEMBL9132111 | 0.80 | CTSC (0.60) | CTSCMMP2 | |
| SCHEMBL7361631 | 0.80 | ITGB3 (0.52) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105175418-B | Pentacyclic indole quinolizine for inhibiting autophagy of cells, synthesis, antitumor activity and application thereof | 首都医科大学 | 2020-01-14 | — | — | CN | claimed |
| CN-105175418-A | Pentacyclic indole quinolizine inhibiting cell autophagy, synthesis, antitumor activity and application thereof | UNIV CAPITAL MEDICAL SCIENCES | 2015-12-23 | — | — | CN | claimed |
| CN-105175418-B | Pentacyclic indole quinolizine for inhibiting autophagy of cells, synthesis, antitumor activity and application thereof | 首都医科大学 | 2020-01-14 | — | — | CN | disclosed |
| CN-105175418-A | Pentacyclic indole quinolizine inhibiting cell autophagy, synthesis, antitumor activity and application thereof | UNIV CAPITAL MEDICAL SCIENCES | 2015-12-23 | — | — | CN | disclosed |