Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 9/20 | 0.38 |
| ▸ | TYR | P14679 | 2/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002718 | 0.77 | TRIM24 (0.44) | ERN1TYRTRIM24TRIM33KDM4E | |
| SCHEMBL29459676 | 0.77 | TRIM24 (0.44) | ERN1TYRTRIM24TRIM33KDM4E | |
| SCHEMBL29459704 | 0.75 | ERN1 (0.50) | ERN1TYRTRIM24TRIM33KDM4E | |
| SCHEMBL670303 | 0.75 | ERN1 (0.50) | ERN1TYRTRIM24TRIM33KDM4E | |
| SCHEMBL12760732 | 0.74 | ERN1 (0.55) | ERN1TYRTRIM24TRIM33ALDH1A1 | |
| SCHEMBL3965959 | 0.73 | TRPA1 (0.41) | KDM4EALDH1A1KMT2ANPSR1PIM1 | |
| SCHEMBL18729174 | 0.72 | ERN1 (0.48) | ERN1TYRTRIM24TRIM33KDM4E | |
| SCHEMBL767452 | 0.71 | ERN1 (0.50) | ERN1TYRTRIM24TRIM33KDM4E | |
| SCHEMBL30400746 | 0.71 | ERN1 (0.50) | ERN1TYRTRIM24TRIM33KDM4E | |
| SCHEMBL5724597 | 0.71 | ERN1 (0.46) | ERN1TYRTRIM24TRIM33ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189485-B | It is used as the novel propylene amide derivatives of anti-malarial agents | 埃科特莱茵药品有限公司 | 2017-10-24 | — | — | CN | disclosed |
| CN-105189485-A | Novel acrylamide derivatives as antimalarial agents | ACTELION PHARMACEUTICALS LTD | 2015-12-23 | — | — | CN | disclosed |